Published in IJCP May 2018
Fasting Serum Magnesium Levels in Patients with Uncontrolled and Controlled T2DM in Relation to Its Complications
May 04, 2018 | Shashidhar G, Suraj R Bhutada, Manjunath U, Prashanth Gk, Vinodh

Background: Magnesium deficiency is proposed factor in pathogenesis of diabetic complications. Hypomagnesemia can be both a cause and consequence of diabetic complications. Objective: The aim of our study was to know the relationships between magnesium levels and diabetes its association with level of control of diabetes. Study design: This study was done in MVJ Medical College and Research Hospital, Hoskote, Bangalore. A total of 75 cases of type 2 diabetes mellitus (T2DM) were taken for study after satisfying the inclusion and exclusion criteria and also 35 nondiabetic patients admitted during this period were also included in this study under control group. All the patients were evaluated in detail including fasting blood sugar (FBS), postprandial blood sugar (PPBS), glycated hemoglobin (HbA1c) and fasting serum magnesium levels were estimated by using Calmagite method. Results: The serum magnesium among cases and controls are 1.88 ± 0.28 mg/dL and 2.10 ± 0.29 mg/dL, respectively. The mean serum magnesium levels in patients with controlled diabetes were 2.04 mg/dL, while they were 1.73 mg/dL in uncontrolled T2DM. Significant association was found between hypomagnesemia and diabetic retinopathy and nephropathy. Conclusions: There was significant reduction in serum magnesium levels in diabetics compared to controls. There was significant correlation between magnesium levels and levels of control in diabetics. Uncontrolled diabetics had low levels of serum magnesium. Duration of diabetes and high levels FBS also had an association with low magnesium levels. Low magnesium levels were mainly associated with diabetic retinopathy and nephropathy.