Published in IJCP May 2018
Anti-PL-12: Antisynthetase Syndrome
May 04, 2018 | Tuhina Parveen Sarwala, Manish N Mehta, Ajay C Tanna, Jemima Bhaskar, Rajesh Sadiya
Internal Medicine

Lance-Adams syndrome (LAS) is a rare complication of a successful cardiopulmonary resuscitation (CPR) and is often accompanied by post-hypoxic action myoclonus. Less than 200 cases have been reported in medical literature till date. A 50-year-old female presented to the Emergency Department in a state of unconsciousness. Urgent intubation and CPR resulted in stabilization of vitals over a period of few days. On regaining consciousness, the patient developed myoclonus, which was characteristically present only on activity and absent at rest or during sleep. This action myoclonus was troublesome to the patient and interfering in the day-to-day activities of the patient. Patient was started on a combination therapy with levetiracetam and clonazepam, which resulted in marked diminution of myoclonus over a period of 15-20 days. Though LAS is a rare complication, proper diagnosis and prompt management may significantly reduce the morbidity and improves the quality-of-life.