The present study was a pilot study conducted at Nalanda Medical College and Patna Medical College, Patna, Bihar. The study included 120 women with ectopic pregnancy who were given single dose or multiple dose of methotrexate. In our study, the success rate in single dose group was 73.33% and in multiple dose group was 83.33% (p value 0.34) and the difference was statistically insignificant. The study showed that medical management of ectopic pregnancy with single dose IM methotrexate regimen is as effective as multiple dose regimen with lesser side effects and this option should be given to the women fulfilling the inclusion criteria.