Celiac disease is an immune-mediated disease due to gluten and related prolamins in genetically susceptible individuals. The only option of treatment is lifelong gluten-free diet (GFD). Strict adherence to GFD may be difficult in children and adolescents due to psychosocial factors. A study evaluated the impact of celiac disease and GFD on social interactions of children with celiac disease and their families, in the backdrop of aim to identify predictors of barriers affecting compliance to GFD. Three types of psychosocial impacts as predictors of barriers to compliance were noted - those caused by effect of celiac disease on feelings of children suffering from celiac disease; barriers derived from parent’s attitude; and those derived from child’s attitude.