Published in IJCP
Newer and Emerging Topical Therapies in Dermatology
December 11, 2018 | Satish DA, Radhika VK, Aparna AD
Fenticonazole is an imidazole antifungal agent used to treat fungal infections of the vagina (Vulvovaginal candidiasis). It is active against a range of organisms including dermatophytes, Malassezia furfur and Candida albicans. It is not recommended for usage in pregnancy and lactation. Side effects include local reactions like burning sensation, itching and rash, which are rare.
Fenticonazole nitrate is available for topical use as a 2% cream. Fenticonazole acts by inhibition of the synthesis of aspartate (acid) proteinase, a virulence enzyme of C. albicans correlated with the adherence of the yeast to epithelial cells.