Published in IJCP
A Comparative Study of Safety Profile and Efficacy of Acyclovir and Ganciclovir in Viral Corneal Ulcer
March 11, 2019 | Rajender Singh Chauhan, Ashok Rathi, Aparna Yadav, Jp Chugh, Ravinder Rose
Objective: The present study was conducted to evaluate the safety profile and efficacy of ganciclovir in cases of viral
corneal ulcer and to compare it with acyclovir. Material and methods: It was a randomized controlled comparative study
undertaken at the Regional Institute of Ophthalmology, Pt BD Sharma PGIMS, Rohtak, Haryana. The patients were divided
into two groups of 25 each. Group I received acyclovir 3% ointment and Group II received ganciclovir 0.5% gel. Patients were
followed-up weekly for 1 month. Efficacy of the drug was assessed in terms of visual acuity and extent of healing. Safety
profile was assessed by development of ocular irritation, blurring of vision and iatrogenic diffuse punctate keratopathy.
The observations were analyzed using unpaired and paired ‘t’ test and Chi-square test. Results: By 14th day, 80% ulcers
were healed in Group I while 88% were healed in Group II. The best corrected visual acuity after healing was also similar
in the two groups (p = 0.730). The safety profile in terms of ocular irritation, blurring of vision and punctate keratopathy
of both the drugs was found to be similar. Conclusion: The efficacy and safety profile of both the drugs was similar in the
treatment of viral corneal ulcer.